Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent
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چکیده
منابع مشابه
Preparation of gold nanoparticle-DNA conjugates.
This unit describes the preparation of conjugates between nanometer-scale gold particles and synthetic oligonucleotides. Oligonucleotide-functionalized gold nanoparticles are finding increased use in both the construction of complex, tailored nanostructures and the optimization of DNA sequence analysis. The protocols in this unit outline the synthesis, purification, and characterization of nano...
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Integration of noble metal nanoparticles with proteins offers promising potential to create a wide variety of biosensors that possess both improved selectivity and versatility. The multitude of functionalities that proteins offer coupled with the unique optical properties of noble metal nanoparticles can allow for the realization of simple, colorimetric sensors for a significantly larger range ...
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Gold nanoparticle (AuNP)-DNA conjugates can enhance in vitro translation of a protein. Enhancement occurs via a combination of nonspecific adsorption of translation-related molecules and the ribosome to the AuNP-DNA and specific binding to the mRNA of interest. AuNP-DNA conjugates enhanced protein production of fluorescent proteins (mCherry, eGFP) in retic lysate mixes by 65-100%. Gel electroph...
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Materials. DOTAP (1,2-dioleoyloxypropyl)-N,N,N-trimethylammonium chloride), DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and cholesterol (Chol) were purchased from Avanti Polar lipids (USA). Solvents (chloroform and methanol) were obtained from Fisher Scientific (UK). Scrambled siRNA and apoptotic siPLK1 were purchased from Eurogentec (Southampton, UK). The fluorescence dye NIR-797 (λex...
متن کاملTrypsin-gold nanoparticle conjugates: binding, enzymatic activity, and stability.
Nanomaterials may interact with biomolecules in various ways and change their bioactivities. Here, we report on how gold nanoparticles (AuNPs) affect a most important protease, trypsin. After simple mixing of the trypsin and AuNPs solution the average diameter is 20 nm under enzyme friendly conditions (pH 8.0); the bond between trypsin and AuNPs was detected by UV-vis spectroscopy. The further ...
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ژورنال
عنوان ژورنال: Pharmaciana
سال: 2017
ISSN: 2477-0256,2088-4559
DOI: 10.12928/pharmaciana.v7i2.6725